期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 431, 期 2, 页码 131-135出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.01.010
关键词
Hydrogen sulfide; Cystathionine gamma-lyase; Calcium; Pyridoxal 5 '-phosphate
资金
- National Institute of Neuroscience
- JSPS KAKENHI [23659089, 23790316, 23700434]
- Grants-in-Aid for Scientific Research [23700434, 23659089, 23790316] Funding Source: KAKEN
Hydrogen sulfide (H2S) is recognized as a physiologic mediator produced in a variety of tissues. It is produced by three enzymes, cystathionine p-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST). However, the regulation of H2S production by CSE has not well been understood. Here we show that H2S producing activity of CSE is regulated by intracellular Ca2+ concentrations. In the presence of pyridoxal 5'-phosphate (PLP) CSE efficiently produces H2S at the steady-state low Ca2+ concentrations but is suppressed at high Ca2+ concentrations. In the absence of PLP H2S production maintains the suppressed levels at high Ca2+ concentrations and decreased further at low Ca2+ concentrations. These observations suggest that CSE produces H2S at the steady-state in cells and that the production is suppressed when the intracellular Ca2+ concentrations are increased. (C) 2013 Elsevier Inc. All rights reserved.
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