期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 431, 期 2, 页码 348-353出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2012.12.093
关键词
Resveratrol; Bone marrow-derived dendritic cells; Indoleamine 2,3-dioxygenase; Anti-tumor activity
资金
- National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea [1120390]
- Korea Health Promotion Institute [1120390] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study showed the potential of resveratrol to inhibit the expression and activity of interferon-gamma (IFN-gamma)-induced indoleamine 2,3-dioxygenase (IDO) in bone marrow-derived dendritic cells (BMDCs). The mechanism of suppression was associated with the activity of Janus kinase/signal transducers and activators of transcription (JAK/STAT) and protein kinase C delta (PKC delta). In addition, resveratrol-mediated IDO suppression in IFN-gamma-stimulated BMDCs appears to play a pivotal role in anti-tumor activity through the regulation of CD8(+) T cell polarization and cytotoxic T lymphocyte (CTL) activity. Systemic administration of resveratrol suppressed tumor growth in EG7 thymoma-bearing mice in an IDO-dependent manner. Taken together, resveratrol not only regulates immune response through the regulation of IDO in a JAK/STAT1- and PKC delta-dependent manner, but also modulates the IDO-mediated immune tolerance in EG7 thymoma. (C) 2012 Elsevier Inc. All rights reserved.
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