期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 441, 期 2, 页码 327-332出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.10.046
关键词
TRPV2; Astrocyte; Lysophosphatidylcholine; Temperature; Cerebellum; Glia
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [21200012, 20399554, 24111507, 23650159]
- Uehara Memorial Foundation
- Takeda Science Foundation, Tokyo, Japan
- Sumitomo Foundation
- Brain Science Foundation
- Narishige Neuroscience Research Foundation
- Salt Science Research Foundation [12C2]
- Grants-in-Aid for Scientific Research [21200012, 23650159, 24111507] Funding Source: KAKEN
Thermosensitive transient receptor potential (thermo TRP) channels are important for sensory transduction. Among them, TRPV2 has an interesting characteristic of being activated by very high temperature (>52 degrees C). In addition to the heat sensor function, TRPV2 also acts as a mechanosensor, an osomosensor and a lipid sensor. It has been reported that TRPV2 is expressed in heart, intestine, pancreas and sensory nerves. In the central nervous system, neuronal TRPV2 expression was reported, however, glial expression and the precise roles of TRPV2 have not been determined. To explore the functional expression of TRPV2 in astrocytes, the expression was determined by histological and physiological methods. Interestingly, TRPV2 expression was detected in plasma membrane of astrocytes, and the astrocytic TRPV2 was activated by very high temperature (>50 degrees C) consistent with the reported characteristic. We revealed that the astrocytic TRPV2 was also activated by lysophosphatidylcholine, a known endogenous lipid ligand for TRPV2, suggesting that astrocytic TRPV2 might regulate neuronal activities in response to lipid metabolism. Thus, for the first time we revealed that TRPV2 is functionally expressed in astrocytes in addition to neurons. (C) 2013 Elsevier Inc. All rights reserved.
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