期刊
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
卷 54, 期 3, 页码 138-144出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/mp.54.3.138
关键词
insulin-like growth factors; insulin-like growth factor binding proteins; insulin-like growth factor I receptor; insulin-like growth factor II/mannose 6-phosphate receptor; hepatocarcinogenesis; hepatocellular carcinoma
类别
Deregulation of the insulin-like growth factor (IGF) axis, including the autocrine production of IGFs, IGF binding proteins (IGFBPs), IGFBP proteases, and the expression of the IGF receptors, has been identified in the development of hepatocellular carcinoma (HCC). Characteristic alterations detected in HCC and hepatoma cell Lines comprise the creased expression of IGF-II an IGF-I receptor (IGIF-IR), which nave emerged as crucial events in malignant transformation and the growth of tumours. Alterations of IGFBP production and the proteolytic degradation of IGFBPs resulting in an excess of bioactive IGFs, as well as the defective function of the IGF degrading IGF-II/mannose 6-phosphate receptor may further potentiate effects of IGFs in the HCC.
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