期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 431, 期 1, 页码 52-57出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2012.12.094
关键词
hYKL-39; Chi-Iectin; Osteoarthritis; Rheumatoid arthritis
资金
- Japan Society for the Promotion of Science [22570135, 22600002, 23592206]
- Global Center of Excellence (GCOE) Program
- International Research Center for Molecular Science in Tooth and Bone Diseases
- Realization of Regenerative Medicine
- Grants-in-Aid for Scientific Research [23592206, 22600002, 25460716, 25293317, 22570135] Funding Source: KAKEN
Human YKL39 (chitinase 3-like protein 2/CHI3L2) is a secreted 39 kDa protein produced by articular chondrocytes and synoviocytes. Recent studies showed that hYKL-39 expression is increased in osteoarthritic articular chondrocytes suggesting the involvement of hYKL-39 in the progression of osteoarthritis (OA). However little is known regarding the molecular function of hYKL-39 in joint homeostasis. Sequence analyses indicated that hYKL-39 has significant identity with the human chitotorisidase family molecules, although it is considered that hYKL-39 has no enzymatic activity since it lacks putative chitinase catalytic motif. In this study, to examine the molecular function of hYKL-39 in chondrocytes, we overexpressed hYKL-39 in ATDC5 cells. Here we report that hYKL-39 enhances colony forming activity, cell proliferation, and type II collagen expression in these cells. These data suggest that hYKL-39 is a novel growth and differentiation factor involved in cartilage homeostasis. (C) 2013 Elsevier Inc. All rights reserved.
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