期刊
VIRUS RESEARCH
卷 75, 期 2, 页码 169-177出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0168-1702(01)00238-6
关键词
pests des petits ruminants virus; rinderpest virus; hemagglutinin-neuraminidase protein hemadsorption; neuraminidase; fusion promotion
类别
The genes coding for the surface glycoproteins hemagglutinin-neuraminidase (HN) of the pests des petits ruminants virus (PPRV) and hemagglutinin (H) of rinderpest virus (RPV) were cloned in a cytomagalovirus promoter driven expression vector and expressed transiently in mammalian cells. The protein expression was apparent 24 h after transfection and the expressed proteins were detected at the cell surface. The transiently expressed PPRV HN protein was found to be biologically active in possessing hemadsorption and neuraminidase activities. On the other hand. RPV H protein exhibited neuraminidase activity but was deficient in hemadsorption activity. The substrate specificity of the neuraminidase activity of these two proteins differed distinctly. The presence of neuraminidase activity in both PPRV HN and RPV H proteins is unusual among members of the morbillivirus genus. (C) 2001 Elsevier Science B.V. All rights reserved.
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