期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 431, 期 3, 页码 382-387出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2013.01.043
关键词
BMAL1; O-GlcNAcylation; Stability; Transcriptional activity; Circadian rhythms
资金
- Major State Basic Research Development Program of China (973 program) [2012CB517904]
- National Natural Science Foundation of China [30970958, 81070481, 81260160]
- Lotus Scholar Professorship Funds from Hunan Province Government
- Central South University of China
Various physiological processes and behaviors show a circadian rhythm of approximately 24 h, which is crucial in coordinating internal metabolic processes and environmental signals. Post-translational modifications play an important role in regulating circadian core proteins. In this study, we demonstrated that BMAL1 was modified with an O-linked beta-N-acetylglucosamine (O-GlcNAc), which stabilized BMAL1 and enhanced its transcriptional activity. Conversely, inhibition of O-GlcNAcylation resulted in inhibition of circadian rhythms of clock gene expression. Because O-GlcNAcylation is sensitive to the glucose level, such a modification may provide a new mechanism connecting metabolism with circadian rhythms. (C) 2013 Elsevier Inc. All rights reserved.
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