期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 430, 期 3, 页码 1120-1125出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2012.12.027
关键词
Infection; Bacteria; Innate immunity; Drosophila; Antimicrobial peptide
资金
- Japanese Ministry of Education, Science, Sports, Culture and Technology
- Funding Program for Next Generation World-Leading Researchers (NEXT Program)
- Grants-in-Aid for Scientific Research [12J11042, 25660223, 23658235] Funding Source: KAKEN
Upon microbial invasion the innate immune system of Drosophila melanogaster mounts a response that comes in two distinct but complimentary forms, humoral and cellular. A screen to find genes capable of conferring resistance to the Gram-positive Staphylococcus aureus upon ectopic expression in immune response tissues uncovered imd gene. This resistance was not dependent on cellular defenses but rather likely a result of upregulation of the humoral response through increased expression of antimicrobial peptides, including a Toll pathway reporter gene drosomycin. Taken together it appears that Imd pathway is capable of playing a role in resistance to the Gram-positive S. aureus, counter to notions of traditional roles of the Imd pathway thought largely to responsible for resistance to Gram-negative bacteria. (C) 2012 Elsevier Inc. All rights reserved.
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