期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 45, 期 6, 页码 1930-1933出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.45.6.1930-1933.2001
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We report that 2 mug of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.
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