期刊
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
卷 54, 期 3, 页码 133-137出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/mp.54.3.133
关键词
insulin-like growth factor 1 receptor; differentiation; insulin receptor substrate 1; transformation
类别
资金
- NCI NIH HHS [P01 CA078890, CA 78890] Funding Source: Medline
The type 1 insulin-like growth factor receptor (IGF-IR) sends several signals, some of which are contradictory. When the concentrations of insulin receptor substrate 1 (IRS-1), a major substrate of the IGF-IR, are high, the signal is mitogenic, anti-apoptotic, and can even cause malignant transformation. However, in the absence of IRS-1, the IGF-IR sends a differentiation signal, which leads to granulocytic differentiation in haemopoietic cells. The mitogenic signal of the IGF-IR/IRS-1 combination depends largely, but not exclusively, on the activation of the phosphatidylinositol-3 kinase (PI3K).
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