期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 418, 期 1, 页码 81-86出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2011.12.134
关键词
Hybrid liposomes; Hepatocellular carcinoma; Apoptosis; Membrane fluidity
资金
- Ministry of Education, Science, and Culture of Japan [20107007, 20360377]
- Grants-in-Aid for Scientific Research [20360377, 20107001, 24656509, 20107007] Funding Source: KAKEN
Hybrid liposomes (HLs), composed of L-alpha-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(23) dodecyl ether, have selectively inhibited the growth of human hepatocellular carcinoma (HCC) cells without affecting normal hepatocytes to trigger apoptosis via caspase-3 activation. Furthermore, HLs distinguished between the HCC and normal cells which had higher and lower membrane fluidities respectively, then fused and accumulated preferentially into the membranes of HCC cells. It is noteworthy that the anti-cancer activity of HLs correlated well with the fluidity of cell membranes for HCC and other cancer cells. These results suggest that HLs could target cancer cell-membranes in relation to their lipid fluidity that provide the possibility of novel nanotherapy for intractable cancer. (C) 2012 Elsevier Inc. All rights reserved.
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