期刊
CLINICAL AUTONOMIC RESEARCH
卷 11, 期 3, 页码 145-154出版社
SPRINGER HEIDELBERG
DOI: 10.1007/BF02329922
关键词
autoantibody; calcium channel; enteric nervous system; sympathetic; parasympathetic; paraneoplastic; transmitter release
Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder characterized by muscle weakness and autonomic dysfunction. Recent ex vivo and in vitro studies demonstrate that autoantibodies to the P/Q-subtype of voltage-gated calcium channel inhibit transmitter release from parasympathetic, sympathetic, and enteric neurons, a mechanism likely to underlie the widespread autonomic dysfunction in LEMS. This review summarizes clinical studies characterizing the autonomic symptoms and signs in LEMS and the effectiveness of treatment in alleviating these symptoms. Serological assays and in vitro pharmacologic and electrophysiologic studies are also discussed.
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