期刊
CURRENT OPINION IN IMMUNOLOGY
卷 13, 期 3, 页码 332-338出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(00)00223-5
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Biochemical experiments have established that the metabolism of inositol phospholipids by phosphoinositide 3-kinases (PI3Ks) and lipid-phosphatases is triggered by many receptors that control T lymphocyte function, including antigen-receptors, costimulatory molecules, cytokines and chemokines. Novel effectors of PI3K have been identified in the immune system and shown to be important in the control of lymphocyte activation. Moreover, key lipid-phosphatases have been identified that act to terminate or modulate PI3K signalling in cells of the immune system.
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