期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 220, 期 1-2, 页码 53-62出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-5173(01)00646-9
关键词
6-fluoroquinolones; partition coefficients; minimal inhibitory concentration; log P
Partitioning of a fluoroquinolone antibiotic, ciprofloxacin, and its N-piperazinyl alkyl derivatives, between octanol or Escherichia toll lipid membrane extract and aqueous buffer pH 7.4, was studied. The experimental partition coefficients (P-exp) were corrected at this pH using an expression that includes the microconstant values of each compound. The relationship between the corrected partition coefficients expressed as log P (thermodynamic partition coefficient) and the diffusion through the lipid bilayers ('hydrophobic pathway') of entry has been considered here. In this work, we have explored the possibility of using our model to provide physicochemical evidences to support such a via. The correlation between log P values and antibacterial activities (expressed as minimal inhibitory concentration (MIC) values) of the homologous series of antibiotics against different bacteria were studied. A parabolic behaviour was observed which evidenced that the only increase in lipophilicity does not result in an enhanced antimicrobial activity for the homologous family studied. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据