期刊
JOURNAL OF NEUROBIOLOGY
卷 47, 期 3, 页码 176-182出版社
JOHN WILEY & SONS INC
DOI: 10.1002/neu.1025
关键词
knock-out; medial preoptic nucleus; ventromedial nucleus; development
资金
- NICHD NIH HHS [HD37244] Funding Source: Medline
- NIMH NIH HHS [MH47538, MH 55562] Funding Source: Medline
Around the time of birth, male rats express higher levels of progesterone receptors in the medial preoptic nucleus (MPN) than female rats, suggesting that the MPN may be differentially sensitive to maternal hormones in developing males and females. Preliminary evidence suggests that this sex difference depends on the activation of estrogen receptors around birth. To test whether estrogen receptor alpha (ER alpha) is involved, we compared progesterone receptor immunoreactivity (PRir) in the brains of male and female neonatal mice that lacked a functional ERa! gene or were wild type for the disrupted gene. We demonstrate that males express much higher levels of PRir in the MPN and the ventromedial nucleus of the neonatal mouse brain than females, and that PRir expression Is dependent on the expression of ER alpha in these regions. In contrast, PRir levels in neocortex are not altered by ER alpha gene disruption. The results of this study suggest that the induction of PR via ER alpha may render specific regions of the developing male brain more sensitive to progesterone than the developing female brain, and may thereby underlie sexual differentiation of these regions. (C) loot John Wiley & Sons. Inc.
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