期刊
FEBS LETTERS
卷 498, 期 2-3, 页码 145-149出版社
WILEY
DOI: 10.1016/S0014-5793(01)02489-9
关键词
nuclear trafficking; nucleoporin; molecular interaction; cell biology
The trafficking of macromolecules between cytoplasm and nucleus through nuclear pore complexes is mediated by specific carrier molecules such as members of the importin-beta family. Nuclear pore proteins (nucleoporins) frequently contain sequence repeats based on FG cores and carriers appear to move their cargo through the pores by hopping beta een successive FG cores. A major question is why some macromolecules are transported while others are not, This selectivity may be generated by the ability to bind FG repeats, a local concentration of carrier-cargo complexes near the entrance to the pore channel, and steric hindrance produced by high concentrations of nucleoporins in the channel. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B,V, All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据