期刊
FEBS LETTERS
卷 498, 期 2-3, 页码 204-207出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)02486-3
关键词
protein conformational disorders; amyloid; protein misfolding; therapy; beta-sheet breaker peptides
Diverse human disorders, including several neurodegenerative diseases and systemic amyloidosis, are thought to arise from the misfolding and aggregation of an underlying protein, Recent findings strongly support this hypothesis and have increased our understanding of the molecular mechanism of protein conformational disorders. Many questions are still pending, but the data overall suggest that correction of protein misfolding constitutes a viable therapeutic strategy for conformational diseases, (C) 2001 Federation of European Biochemical Societies, Published by Elsevier Science B,V, All rights reserved.
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