期刊
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
卷 285, 期 22, 页码 2888-2890出版社
AMER MEDICAL ASSOC
DOI: 10.1001/jama.285.22.2888
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资金
- NCRR NIH HHS [M01 RR03186] Funding Source: Medline
- NHLBI NIH HHS [R01HL62252] Funding Source: Medline
- NIA NIH HHS [T32 AG00164, R01 AG14124] Funding Source: Medline
- NIMH NIH HHS [P30 MH40041] Funding Source: Medline
- NINDS NIH HHS [P50 NS23724] Funding Source: Medline
Context Apolipoprotein E epsilon4 (ApoE epsilon4) is a well-known risk factor for Alzheimer disease and cardiovascular disease. Sleep-disordered breathing occurs in Alzheimer disease patients and increases risks for cardiovascular disease. Complex interactions among sleep, brain pathology, and cardiovascular disease may occur in ApoE epsilon4 carriers, Objective To study whether genetic variation at the level of ApoE is associated with sleep-disordered breathing or sleep abnormalities in the general population. Design, Setting, and Participants Ongoing longitudinal cohort study of sleep disorders at a US university beginning in 1989, providing a population-based probability sample of 791 middle-aged adults (mean [SD] age, 49 [8] years; range, 32-68 years). Main Outcome Measure Nocturnal polysomnography to evaluate apnea-hypopnea index. Results The probability of moderate-to-severe sleep-disordered breathing (apnea-hypopnea index greater than or equal to 15%) was significantly higher in participants with epsilon4, independent of age, sex, body mass index, and ethnicity (12.0% vs 7.0%; P=.003). Mean (SEM) apnea-hypopnea index was also significantly higher in participants with ApoE epsilon4 (6.5 [0.6] vs 4.8 [0.3]; P=.01). These effects increased with the number of ApoE epsilon4 alleles carried. Conclusions A significant portion of sleep-disordered breathing is associated with ApoE epsilon4 in the general population.
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