期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 408, 期 1, 页码 65-70出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2011.03.117
关键词
Proteasome; Immunoproteasome; PA28; Neuroinflammation; Mesial temporal lobe epilepsy; Epilepsy surgery; Neuron
资金
- Italian Ministry of Health [Giovani Ricercatori 2007]
- The European Commission [FP6-518230]
- PERNO
- A.V. Humboldt PostDoc fellowship
Immunoproteasome has been associated to neurodegenerative and autoimmune diseases as a marker and regulator of inflammatory mechanisms. Its expression in the brain may occur upon neuroinflammation in different cell types and affect a variety of homeostatic and inflammatory pathways including the oxidized protein clearance and the self-antigen presentation. In the present study we investigated the immunoproteasome expression in hippocampi and cortex of patients affected by different histopathological forms of pharmaco-resistent mesial temporal lobe epilepsy. We identified a pathology-specific pattern of immunoproteasome expression, which could provide insight into the complex neuroinflammatory pathogenic components of this disease. (C) 2011 Elsevier Inc. All rights reserved.
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