期刊
REGULATORY PEPTIDES
卷 99, 期 2-3, 页码 183-189出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0167-0115(01)00253-1
关键词
ischemic preconditioning; CGRP (calcitonin gene-related peptide); age; heart; rat
In the present study, we examined whether age-related reduction of ischemic preconditioning is related to calcitonin gene-related peptide (CGRP) release in the rat heart. Thirty minutes of global ischemia and 40 min of reperfusion caused a significant decrease of cardiac function and a marked increase of creatine kinase (CK) release at 2, 6 and 20 months of age. Ischemic preconditioning and pretreatment with CGRP for 5 min significantly improved cardiac function and reduced CK release during reperfusion at 2 and 6 months of age but not at 20 months of age. The content of CGRP in the coronary effluent during ischemic preconditioning was significantly increased in the first cycle at 2, 6 months of age but not at 20 months of age. These results suggest that the protection afforded by ischemic preconditioning is decreased in aging hearts, and the age-related change may be related to reduction of the release and effect of CGRP in the rat heart. (C) 2001 Elsevier Science B.V. All rights reserved.
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