期刊
TETRAHEDRON LETTERS
卷 42, 期 25, 页码 4171-4174出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(01)00678-5
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The first total synthesis of lyngbyabellin A, a novel peptolide from the marine cyanobacterium Lyngbya majuscula, is described. Both functionalized thiazole carboxylic acid units were synthesized using our CMD (chemical manganese dioxide) oxidation from the corresponding thiazolidines. The asymmetric synthesis of the dichlorinated beta -hydroxy acid was achieved by the chiral oxazaborolidinone mediated aldol reaction. Finally, fragment condensation followed by the macrolactamization provided lyngbyabellin A. (C) 2001 Elsevier Science Ltd. All rights reserved.
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