期刊
ONCOGENE
卷 20, 期 29, 页码 3776-3785出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204518
关键词
retinoblastoma protein; protein phosphatase type 1; pRB dephosphorylation; PP1 activity
资金
- NCI NIH HHS [CA11198] Funding Source: Medline
pRb is dephosphorylated at mitotic exit by the type 1 serine/threonine protein phosphatases (PP1), Here we demonstrate for the first time that mitotic pRb dephosphorylation is a sequential, temporally-regulated event. We also provide evidence that the three mammalian isoforms of PP1, alpha, gamma -1, and delta, differ in their respective preferences for site-specific pRb dephosphorylation and that the mitotic and G(1) PP1-isoform counterparts exhibit differential activities towards mitotic pRb, Finally, the physiological relevance of the striking contrast between the patterns of Thr821 and Thr826 dephosphorylation, sites known to be important for disrupting binding of LXCXE-containing proteins to pRb, is addressed.
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