期刊
EUROPEAN JOURNAL OF PHARMACOLOGY
卷 423, 期 1, 页码 35-39出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-2999(01)01061-5
关键词
spermidine; arcaine; polyamine; amygdala; learning; memory
In the present study, we investigated the effect of immediate post-training bilateral infusion of spermidine, a polyamine agonist, into the amygdala on inhibitory avoidance learning of rats. Bilateral microinjection of spermidine (0.02-20 nmol) caused an increase in test step-down latencies at high concentrations. Administration of arcaine (0.002-0.2 nmol), an antagonist of the NMDA receptor polyamine binding site, decreased test step-down latencies. On the other hand, co-administration of arcaine and spermidine completely reversed the spermidine-induced increase of test step-down latencies. These results provide evidence that polyamines may be involved in learning and memory modulation in the amygdala. (C) 2001 Elsevier Science B.V. All rights reserved.
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