期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 276, 期 26, 页码 24360-24364出版社
ELSEVIER
DOI: 10.1074/jbc.M102081200
关键词
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Human alveolar macrophages (A-M Phi) and macrophages (M Phi) generated from human monocytes under the influence of granulocyte-macrophage colony-stimulating factors (GM-M Phi) express high Levels of catalase activity and are highly resistant to H2O2. In contrast, M Phi generated from monocytes by macrophage colony-stimulating factors (M-M Phi) express low catalase activity and are about 50-fold more sensitive to H2O2 than GM-M Phi or A-M Phi. Both A-M Phi, and GM-M Phi, but not M-M Phi can induce catalase expression in both protein and mRNA levels when stimulated with H,OZ or zymosan. M-M Phi but not GM-M Phi, produce a Large amount of H2O2 in response to zymosan or heat-killed Staphylococcus aureus. These findings indicate that GM-M Phi, and A-M Phi but not M-X Phi are strong scavengers of H2O2 via the high basal level of catalase activity and a marked ability of catalase induction and that catalase activity of M Phi is regulated by colony-stimulating factors during differentiation.
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