期刊
IMMUNITY
卷 15, 期 1, 页码 149-158出版社
CELL PRESS
DOI: 10.1016/S1074-7613(01)00164-9
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资金
- NCI NIH HHS [P30 CA016042] Funding Source: Medline
- NIAID NIH HHS [AI 07126-23] Funding Source: Medline
- NIDDK NIH HHS [DK46763, DK43026, P01 DK046763] Funding Source: Medline
An aberrant T cell response to enteric bacteria is important in inflammatory bowel disease. However, the identity of relevant microbial antigens is unknown. Here, we report the presence of I2, a Crohn's disease-associated microbial gene, in the murine intestine. The I2 protein induced a proliferative and IL-10 response by CD4(+) T cells from unimmunized mice. The I2 response was dependent on MHC class I1-mediated recognition but did not require antigen processing. Selective activation was observed for the TCR-V beta5 subpopulation. These findings indicate that the I2 protein is a new class of T cell superantigen and suggest that colonization by the I2 microorganism in susceptible hosts may provide a superantigenic stimulus pertinent to Crohn's disease pathogenesis.
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