期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 391, 期 2, 页码 1192-1196出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.12.029
关键词
Streptococcus sanguinis; Pili; Fibronectin binding
资金
- Japan Society for the Promotion of Science [19209063, 16390605, 20390465, 20592398, 18689050, 21659423, 21689052, 19791343, 21792069, 18073011]
- Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [20592398, 20390465, 18073011, 21659423, 19791343, 21792069] Funding Source: KAKEN
Streptococcus sanguinis is a predominant bacterium in the human oral cavity and occasionally causes infective endocarditis. We identified a unique cell surface polymeric structure named pili in this species and investigated its functions in regard to its potential virulence. Pili of S. sanguinis strain SK36 were shown to be composed of three distinctive pilus proteins (PilA. PilB, and PilC), and a pili-deficient mutant demonstrated reduced bacterial adherence to HeLa and human oral epithelial cells. PilC showed a binding ability to fibronectin, suggesting that pili are involved in colonization by this species. In addition, ATCC10556, a standard S. sanguinis strain, was unable to produce pili due to defective pilus genes, which indicates a diversity of pilus expression among various S. sanguinis strains. (C) 2009 Elsevier Inc. All rights reserved.
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