期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 396, 期 1, 页码 90-94出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.02.162
关键词
Adverse drug reactions; Drug metabolism; Clopidogrel; CYP2C19; CYP2D6
资金
- The Swedish Research Council
- The Swedish Cancer Society
- Vinnova
- Hjarnfonden
- Torsten and Ragnar Soderbergs Stiftelser
Important interindividual differences in drug pharmacokinetics cause absence of drug response or adverse drug reactions in significant fractions of the populations. The identification of the major enzymes participating, and the elucidation of the genetic basis for this variation in particular among cytochromes P450, provide tools for a personalized medicine treatment, which can make drug therapy much more effective at a lower cost. Much of the pioneering work linking drug metabolizing phenotype to genetic polymorphism among the P450 enzymes has been carried out at Karolinska Institutet. In this review we give a background and description of this work as well as the important implications for future medicine. (C) 2010 Elsevier Inc. All rights reserved.
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