期刊
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
卷 6, 期 3, 页码 339-353出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/A:1011379725811
关键词
mucin; breast cancer; signal transduction; immunotherapy; glycosylation; immune modulation
资金
- NCI NIH HHS [CA81703, CA64389] Funding Source: Medline
- NHLBI NIH HHS [HL07897] Funding Source: Medline
MUC1 is a large, heavily glycosylated mucin expressed on the apical surfaces of most simple, secretory epithelia including the mammary gland, gastrointestinal, respiratory, urinary and reproductive tracts. Although MUC1 was thought to be an epithelial-specific protein, it is now known to be expressed on a variety of hematopoietic cells as well. Mucins function in protection and lubrication of epithelial surfaces. Transmembrane mucins, which contain cytoplasmic tail domains, appear to have additional functions through their abilities to interact with many proteins involved in signal transduction and cell adhesion. The goal of this review is to highlight recent discoveries that suggest that MUC1 may be a multifunctional protein, located on the surfaces of cells as a sensor of the environment, poised to signal to the interior when things go awry.
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