期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 402, 期 2, 页码 252-257出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.10.010
关键词
ChREBP; Pdx-1; MafA; Insulin; Glucokinase; Gene expression; Pancreatic beta-cells; MIN6; Islets of Langerhans
资金
- Diabetes UK [RD04/0002895]
- Wellcome Trust [WT082366MA, 081958/2/07/Z]
- European Union
- Medical Research Council [G0401641]
- Medical Research Council [G0401641] Funding Source: researchfish
- MRC [G0401641] Funding Source: UKRI
Carbohydrate responsive element-binding protein (ChREBP) is a transcription factor whose expression and activity are increased in pancreatic beta-cells maintained at elevated glucose concentrations. We show here that ChREBP inactivation in clonal pancreatic MIN6 beta-cells results in an increase in Pdx-1 expression at low glucose and to a small, but significant, increase in Ins2, GcK and MafA gene expression at high glucose concentrations. Conversely, adenovirus-mediated over-expression of ChREBP in mouse pancreatic islets results in decreases in Pdx-1, MafA, Ins1, Ins2 and GcK mRNA levels. These data suggest that strategies to reduce ChREBP activity might protect against beta-cell dysfunction in type 2 diabetes. (C) 2010 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据