4.2 Article

Expression analysis of the histamine H3 receptor in developing rat tissues

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MECHANISMS OF DEVELOPMENT
卷 105, 期 1-2, 页码 167-173

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ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00389-6

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histamine; H-3 receptor; L-histidine decarboxylase; rat; in situ hybridization; reverse transcriptase polymerase chain reaction analysis; MAP kinase activity; tissue growth; cell proliferation

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Endogenous histamine is involved in tissue growth and cell proliferation. In accordance with a putative function of the H-3 receptor in this mitogenic effect, we show that H-3-receptor mRNAs are expressed together with those of the histamine-synthesizing enzyme in the embryonic liver and adipose tissue, and in various epithelia. Finally, we show that activation of recombinant H3 receptors enhances MAP kinase activity. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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