期刊
NATURE NEUROSCIENCE
卷 4, 期 7, 页码 695-701出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/89482
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资金
- NINDS NIH HHS [NS38877] Funding Source: Medline
Slit proteins are a family of secreted guidance proteins that can repel neuronal migration and axon growth via interaction with their cellular roundabout receptors (Robos). Here it was shown that Slit2-Robo-1 interactions were enhanced by cell-surface heparan sulfate. Removal of heparan sulfate decreased the affinity of Slit for Robe by about threefold. In addition, removal of cell-surface heparan sulfate by heparinase III abolished the chemorepulsive response to Slit2 normally shown by both the migrating neurons and growing axons. These results indicate essential roles for cell-surface heparan sulfate in the repulsive activities of Slit2.
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