期刊
ACTA NEUROLOGICA SCANDINAVICA
卷 104, 期 1, 页码 36-43出版社
WILEY
DOI: 10.1034/j.1600-0404.2001.00308.x
关键词
Gilles de la Tourette Syndrome; Obsessive-Compulsive Disorder; motor inhibition; frontal lobes; event-related potentials
Objectives - The Gilles de la Tourette Syndrome (TS) and Obsessive Compulsive Disorder (OCD) have been shown to display impaired cognitive and motor inhibition. This study investigated inhibitory mechanisms of motor responses in order to expand the understanding of sensorimotor integration processes in both disorders. We hypothesized that both patient groups would display altered frontal inhibitory activity. Material and methods - To this end event-related brain potentials (ERPs) were recorded in a STOP-paradigm in groups of TS and OCD patients and in a control group. The paradigm required the execution of a motor response after a go signal was given and the occasional suppression of this response after a second stop signal occurred. Results - Behavioral parameters and Lateralized Readiness Potential (LRP) confirmed that both patient groups were well able to initiate motor responses. Go and stop stimuli elicited an enhanced frontal negative activity in both patient groups. In addition, stop stimuli were associated with a frontal shift of the NoGo-Anteriorization (NGA) in the TS group but not in the OCD group. Conclusions - The data are interpreted to indicate altered frontal inhibitory functions. Similarities and dissimilarities between the findings for TS and OCD are discussed with respect to other pathophysiologic aspects of the disorders.
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