期刊
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
卷 478, 期 1-2, 页码 1-21出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/s0027-5107(01)00142-7
关键词
cisplatin; trans-DDP; DNA adducts; HMG box proteins; histone H1; TATA binding protein; Y-box binding protein; photolyase; XPE; XPA; RPA; ERCCI; mismatch reapir; 3-methyladenine DNA glycosylase; T4 endonuclease VII and Ku autoantigen
资金
- NCI NIH HHS [R01 CA086061, CA86061] Funding Source: Medline
Cisplatin is a widely used chemotherapeutic agent. It reacts with nucleophilic bases in DNA and forms 1,2-d(ApG), 1,2-d(GpG) and 1,3-d(GpTpG) intrastrand crosslinks, interstrand crosslinks and monofunctional adducts. The presence of these adducts in DNA is through to be responsible for the therapeutic efficacy of cisplatin. The exact signal transduction pathway that leads to cell cycle arrest and cell death following treatment with the drug is not known but cell death is believed to be mediated by the recognition of the adducts by cellular proteins. Here we describe the structural information available for cisplatin and related platinum adducts, the interactions of the adducts with cellular proteins and the implications of these interactions for cell survival. (C) 2001 Elsevier Science B.V. All rights reserved.
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