期刊
HUMAN REPRODUCTION UPDATE
卷 7, 期 4, 页码 411-418出版社
OXFORD UNIV PRESS
DOI: 10.1093/humupd/7.4.411
关键词
affected sib-pair analysis; endometriosis; genetics; phenotype-genotype; positional cloning
This paper (i) reviews the current clinical and molecular genetic data which strongly suggest that endometriosis has a genetic basis; (ii) outlines the general principles of affected-sib pair analysis; and (iii) describes the Oxford Endometriosis Gene (OXEGENE) Study which aims, using a positional cloning approach, to identify susceptibility genes involved in the development of the disease.
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