期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 1, 期 7, 页码 1249-1259出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-5769(01)00055-8
关键词
mycobacterial cell fractions; cell wall skeleton (CWS); cancer immunotherapy; MDP; TDM; CpG repeats; dendritic cells/macrophages; toll-like receptor; innate immunity
Previously, we have reported that cell-wall skeleton (CWS) fraction was the major adjuvant-active principle of mycobacterial cells which were used in Freund's complete adjuvant (FCA). We have described the biochemical and immunological properties of CWS of mycobacteria and related bacteria, especially the CWS of Mycobacterium boeis BCG strain (BCG-CWS) in derail. The effectiveness of BCG-CWS for the cancer immunotherapy in patients was shown in several clinical trials. On the action mechanism of BCG-CWS on host immune cells, we have suggested that dendritic cells and macrophages express two sorts of receptors, Toll-like receptors, TLR-2 and TLR-4, and a putative binding receptor for BCG-CWS, whose signaling pathways lead to a sufficient antigen-presenting state in the activation of the innate immune system. We have also reported the usefulness of synthetic immunoadjuvants such as muramyldipeptide (MDP) derivatives, trehalose-dimycolates (TDM) and DNA fraction for the application for the cancer and infectious diseases in experimental systems and cancer patients. (C) 2001 Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据