期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 391, 期 1, 页码 248-253出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.11.044
关键词
Apoptosis; Adenine nucleotide translocase; GD3; GD3-7-aldehyde
资金
- Association pour la Recherche Sur le Cancer (ARC)
- EGIDE
- l'Agence Nationale pour la Recherche (ANR) [ANR-08PCVI-0008-01]
- l'Institut National pour le Cancer (INCa) [2008-1-PL BIO-04-CNRS ON1]
We prepared GD3-7-aldehyde (GD3-7) and determined its apoptotic potential. GD3-7 proved to be more efficient to induce pro-apoptotic mitochondrial alterations than GD3 when tested on mouse liver mitochondria GD3-7-induced mitochondrial swelling and depolarization was blocked by cyclosporin A (CsA) supporting a critical role of the permeability transition pore complex (PTPC) during GD3-7-mediated apoptosis In contrast to GD3, GD3-7 was able to induce channel formation in proteoliposomes containing adenine nucleotide translocase (ANT). This suggests chat ANT is the molecular target of GD3-7 Using a specific antiserum, GD3-7 was detected in the lipid extract of the myeloid tumor cell line HL-60 after apoptosis induction, but not in living cells Therefore, GD3-7 might be a novel mediator of PTPC-dependent apoptosis in cancer cells (c) 2009 Elsevier Inc. All rights reserved.
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