期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 402, 期 4, 页码 813-818出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2010.10.127
关键词
Tsukushi; Mouse brain; Axon guidance; Anterior commissure
资金
- PRESTO of the JST
- Takeda Science Foundation
- Brain Science Foundation
- MEXT of Japan
- Kumamoto University 21st Century COE Research
- Kumamoto University Global COE Research
The anterior commissure (AC) is one of the important commissure projections in the brain that conveys information from one side of the nervous system to the other During development the axons from the anterior AC (aAC) and the posterior AC (pAC) course in the same dorsoventral plane and converge into a common fascicle for midline crossing Previously we reported that Tsukushi (TSM) a member of the secreted small leucine rich repeat proteoglycan family functions as a key coordinator of multiple pathways outside of cells through the regulation of an extracellular signaling network Here we show evidence that TSK is critical for the formation of the AC In mice lacking TSK the aAC and the pAC axons fall to cross the midline leading to an almost total absence of the AC in adult mice DiI labeling Indicated that the aAC axons grew out from the anterior olfactory nucleus and migrated along normal pathways but never crossed the midline Therefore we have uncovered a crucial role for TSK for AC formation in the mouse brain (C) 2010 Elsevier Inc All rights reserved
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