期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 18, 期 7, 页码 1168-1175出版社
OXFORD UNIV PRESS
DOI: 10.1093/oxfordjournals.molbev.a003904
关键词
mtDNA recombination; doubly uniparental inheritance; Mytilus; COIII
The: assumption that animal mitochondrial DNA (mtDNA) does not undergo homologous recombination is based on indirect evidence, yet it has had an important influence on our understanding of mtDNA repair and mutation accumulation land thus mitochondrial disease and aging) and on biohistorical inferences made from population data. Recently, several studies have suggested recombination in primate mtDNA on the basis of patterns of frequency distribution and linkage associations of mtDNA mutations in human populations, but others have failed to produce similar evidence, Here, we provide direct evidence for homologous mtDNA recombination in mussels, where heteroplasmy is the rule in males. Our results indicate a high rate of mtDNA recombination. Coupled with the observation that mammalian mitochondria contain the enzymes needed for the catalysis of homologous recombination, these, findings suggest that animal mtDNA molecules may recombine regularly and that the extent to which. this generates: new haplotypes may depend only on the frequency of biparental inheritance of the mitochondrial genome. This, generalization must, however, await evidence from animal species with typical maternal mtDNA inheritance.
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