期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 290, 期 25, 页码 15362-15364出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R115.663708
关键词
apoptosis; autophagy; cancer; cell signaling; ceramide; diabetes; glycolipid; immunology; sphingolipid; neuropathy
资金
- NIGMS NIH HHS [R37 GM028140] Funding Source: Medline
Sphingosine was named by J. L. W. Thudichum for its enigmatic properties. This descriptor has applied to sphingolipids for over a century because new enigmas continue to surface. This JBC minireview series presents articles about three novel subspecies of sphingolipids, -galactosylceramides, 4,5-dihydroceramides, and 1-deoxysphingolipids, that have important activities but, until recently, remained undetected (or at least understudied) in the shadow of very closely related compounds. They also serve as a reminder that important metabolites still lie off the radar screen in reports of global and comprehensive metabolomic profiling.
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