期刊
MOLECULAR BIOLOGY
卷 35, 期 4, 页码 509-520出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1023/A:1010510623805
关键词
ribosome; antibiotics; RNA; erythromycin; telithromycin; linezolid; oxazolidinones; evernimicin
In spite of decades of research, our understanding of the principles of antibiotic binding to the ribosome and the mechanisms of drug action remains only fragmentary. Recent progress in biochemical and genetic studies of some old and new antibiotics and the availability of high-resolution structures of the ribosome subunits allows mapping the antibiotic-binding sites at atomic resolution. In this review, interaction of three groups of antibiotics with the ribosome and the mechanisms of the drug action are discussed, considering the data used to map the binding sites of the new macrolide derivatives, ketolides, a novel clinically important antibiotic linezolid, and a still experimental drug evernimicin.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据