期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 382, 期 2, 页码 405-409出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.03.038
关键词
TDP-43; Phosphorylation; Casein kinase-1; Frontotemporal lobar degeneration with ubiquitin-positive inclusions; Amyotrophic lateral sclerosis; Mass spectrometry
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [20023038, 20300144, 19590297, 19591024]
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [19591024, 20300144, 21591536, 20023038, 19590297] Funding Source: KAKEN
TAR DNA-binding protein of 43 kDa (TDP-43) is deposited as hyperphosphorylated cytoplasmic and intranuclear inclusions in brains of patients with frontotemporal lobar degeneration with ubiquitinated inclusions and amyotrophic lateral sclerosis. In this study, we identified 29 phosphorylation sites on recombinant TDP-43 that are phosphorylated by casein kinase-1 (CK1). Interestingly, 18 of them were located in the C-terminal glycine-rich region of TDP-43. Our results indicate that CK1-mediated phosphorylation may play a role in the pathogenesis of these diseases. (C) 2009 Elsevier Inc. All rights reserved.
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