期刊
IUBMB LIFE
卷 52, 期 1-2, 页码 49-53出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15216540252774766
关键词
AP-1; HIF-1; hypoxia; MAP kinases; VEGF
HIF-1 is the main transcription factor responsible for increased gene expression in hypoxia: VEGF, erythropoietin, GLUT-1, and glycolytic enzymes are such target genes and all participate in the adaptative response of cells to hypoxia. AP-1 activation by hypoxia has also been demonstrated in several cell lines and it cooperates with HIF-1 for increasing VEGF gene transcription in hypoxia. Both HIF-1 and AP-1 activation by hypoxia seems to involve members of the MAP kinase family. Here, we summarize the data indicating that ERK and JNK are needed for activation of HIF-1 and AP-1, respectively.
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