期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 281, 期 1, 页码 H284-H289出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.2001.281.1.H284
关键词
aging; baroreceptor; exercise training
资金
- NIA NIH HHS [AG-00847, AG-06537, AG-16071, AG-13038] Funding Source: Medline
Cardiovagal baroreflex sensitivity (BRS) declines with advancing age in humans, but the underlying mechanism has not been established. Using two different approaches, we determined the relation between age-associated decline in cardiovagal BRS and the compliance of an artery in which arterial baroreceptors are located. First, we measured carotid artery compliance (via the simultaneous application of ultrasonography and arterial applanation tonometry) and cardiovagal BRS (phase IV of the Valsalva maneuver) in 47 healthy sedentary men that varied widely in age (19-76 yr). Cardiovagal BRS declined progressively with age (r = -0.69; P less than or equal to 0.001) and was positively related to carotid artery compliance (r = 0.71; P less than or equal to 0.001). Stepwise multiple-regression analysis revealed that carotid artery compliance was the strongest independent physiological correlate of cardiovagal BRS and that it explained 51% of the total variance. Second, we studied 13 middle-aged and older previously sedentary men (age 56 +/- 2 yr) before and after 13 wk of aerobic exercise intervention. Regular exercise increased both cardiovagal BRS and carotid artery compliance (P<0.05) and the two events were strongly and positively related (r = 0.72; P<0.01). We conclude that reduced carotid artery compliance may play an important mechanistic role in age-associated decrease in cardiovagal BRS in healthy sedentary humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据