期刊
INFECTION AND IMMUNITY
卷 69, 期 7, 页码 4572-4579出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.7.4572-4579.2001
关键词
-
资金
- NIAID NIH HHS [AI48, R01 AI029549, AI29549, R37 AI029549] Funding Source: Medline
- NIDDK NIH HHS [R01 DK051406, DK51406] Funding Source: Medline
The vast majority of urinary tract infections are caused by strains of uropathogenic Escherichia coli that encode filamentous adhesive organelles called type I pill. These structures mediate both bacterial attachment to and invasion of bladder epithelial cells. However, the mechanism by which type 1 pilus-mediated bacterial invasion contributes to the pathogenesis of a urinary tract infection is unknown. Here we show that type 1-piliated uropathogens can invade the superficial epithelial cells that line the lumenal surface of the bladder and subsequently replicate, forming massive foci of intracellular E, coli termed bacterial factories. In response to infection, superficial bladder cells exfoliate and are removed with the how of urine. To avoid clearance by exfoliation, intracellular uropathogens can reemerge and eventually establish a persistent, quiescent bacterial reservoir within the bladder mucosa that may serve as a source for recurrent acute infections. These observations suggest that urinary tract infections are more chronic and invasive than generally assumed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据