期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 383, 期 1, 页码 63-67出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.03.120
关键词
Adipose tissue; Obesity; Human; Carboxylesterase 1; Microarray; Lipolysis
资金
- Swedish Research Council [K2007-55X11285-13-3, K2009-65X-15424-05]
- Swedish Foundation for Strategic Research
- Swedish Diabetes Foundation
- Dr. P. Hakanssons Foundation
- Swedish Federal Government
- Royal Physiographic Society (Nilsson-Ehle Foundation)
- Foundations of the National Board of Health and Welfare
- Ake Wiberg Foundation
- Torsten and Ragnar Soderberg Foundation
- Arosenius Foundation
- Jeansson Foundations
- Tore Nilsson Foundation for Medical Research
- Magnus Bergvall Foundation
- Wellcome Trust [GR079534]
- Medical Research Council [G0600331] Funding Source: researchfish
- MRC [G0600331] Funding Source: UKRI
Carboxylesterase 1 (CES1) has recently been suggested to play a role in lipolysis. Our aim was to Study the regulation of CES1 expression in human adipose tissue. In the SOS Sib Pair Study, CES1 expression was higher in obese compared with lean sisters (n = 78 pairs, P = 8.7 x 10(-18)) and brothers (n = 12 Pairs, P = 0.048). CES1 expression was higher in subcutaneous compared with omental adipose tissue in lean (P = 0.027) and obese Subjects (P = 0.00036), and reduced during diet-induced weight loss (it = 24, weeks 8, 16, and 18 compared to baseline, P < 0.0001 for all time points). CES1 expression was higher in isolated adipocytes compared with intact adipose tissue (P = 0.0018) and higher in large compared with small adipocytes (P = 4.1 x 10(-6)). Basal and Stimulated lipolysis was not different in individuals with high, intermediate, and low expression of CES1. Thus, CES1 expression was linked to body fat and adipocyte fat content but not to lipolytic activity. (C) 2009 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据