期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 387, 期 3, 页码 585-589出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2009.07.066
关键词
Homeostasis; Neuron; Action potential; Threshold potential; Refractory period and sodium channel
资金
- National Award for Outstanding Young Scientist [30325021]
- National Basic Research Program [2006CB500804]
- Natural Science Foundation China [30621130077, 30870517]
- CAS Program for Knowledge Innovation [KSCX2-YWR-39]
Homeostasis of internal environment and cellular metabolism ensures cells' functions to be stable in living organisms. cellular homeostasis is believed to be maintained via feedback or feedforward manners. We report a novel mechanism that maintains neuronal homeostasis through coordinating the intrinsic properties of single molecules concurrently. Spike encoding and sodium channel dynamics at cortical neurons were Studied by patch-clamp recording. Voltage-gated sodium channels set refractory period and threshold potential toward different directions to stabilize the energetic barrier for firing sequential action potentials. This neuronal homeostasis is not affected by intracellular Ca2+ signals and membrane potentials. Real-time homeostasis maintains precise and reliable neuronal encoding without ally destabilization. (C) 2009 Elsevier Inc. All rights reserved.
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