期刊
GENES & DEVELOPMENT
卷 15, 期 13, 页码 1619-1624出版社
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.900101
关键词
TRRAP; histone acetyltransferase; Myc; ATM domain; oncogenesis
The ATM-related TRRAP protein is a component of several different histone acetyltransferase (HAT) complexes but lacks the kinase activity characteristic of other ATM family members. We identified a novel function for this evolutionarily conserved domain in its requirement for the assembly of a functional HAT complex. Ectopic expression of TRRAP protein with a mutation in the ATM-related domain inhibits Myc-mediated oncogenic transformation. The Myc-binding region of TRRAP maps to a separable domain, and ectopic expression of this domain inhibits cell growth. These findings demonstrate that the ATM-related domain of TRRAP forms a structural core for the assembly and recruitment of HAT complexes by transcriptional activators.
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