期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 378, 期 2, 页码 218-223出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2008.11.017
关键词
Rheumatoid arthritis; Adiponectin; Inflammation; Chemokine
资金
- Toho University School of Medicine [19-10, 07-04]
- Ministry of Education, Culture, Sports, Science Technology [20591177]
- Grants-in-Aid for Scientific Research [20591177] Funding Source: KAKEN
The adipokines are linked not only to metabolic regulation, but also to immune responses. Adiponectin, but not leptin or resistin induced interleukin-8 production from rheumatoid synovial fibroblasts (RSF). The culture supernatant of RSF treated with adiponectin induced chemotaxis, although adiponectin itself had no such effect. Addition of antibody against adiponectin, and inhibition of adiponectin receptor gene decreased adiponectin-induced IL-8 production. Nuclear translocation of nuclear factor-kappa B was increased by adiponectin. The induction of interleukin-8 was inhibited by mitogen-activated protein kinase inhibitors. These findings suggest that adiponectin contributes to the pathogenesis of rheumatoid arthritis. (C) 2008 Elsevier Inc. All rights reserved.
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