期刊
BRAIN RESEARCH REVIEWS
卷 35, 期 3, 页码 287-294出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-0173(01)00056-X
关键词
ceruloplasmin; brain iron metabolism; iron efflux and influx; aceruloplasminemia; neurodegenerative diseases
For more than three decades, it has been widely accepted that ceruloplasmin plays an important role in iron efflux from mammalian cells, including brain cells, via the activity of ferroxidase. However, in tight of recent findings, this view might not be completely accurate and the role of ceruloplasmin in brain iron metabolism may need to be re-evaluated. Based on recent studies, we propose in this article that the role of ceruloplasmin in iron uptake by brain neuronal cells might be more important than its role in iron release from the cells. A possible explanation of why the absence of ceruloplasmin induces excessive iron accumulation in neurons in aceruloplasminemia (ceruloplasmin gene mutations) was also discussed. (C) 2001 Elsevier Science B.V. All rights reserved.
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