期刊
IMMUNITY
卷 15, 期 1, 页码 59-70出版社
CELL PRESS
DOI: 10.1016/S1074-7613(01)00173-X
关键词
-
类别
资金
- NIAID NIH HHS [AI38903, T32 AI-07313] Funding Source: Medline
- NIGMS NIH HHS [GM394766] Funding Source: Medline
The widely accepted kinetic proofreading theory proposes that rapid TOR dissociation from a peptide/MHC ligand allows for stimulation of early but not late T cell activation events, explaining why low-affinity TCR ligands are poor agonists. We identified a low-affinity TCR ligand which stimulated late T cell responses but, contrary to predictions from kinetic proofreading, inefficiently induced early activation events. Furthermore, responses induced by this ligand were kinetically delayed compared to its high-affinity counterpart. Using peptide/MHC tetramers, we showed that activation characteristics could be dissociated from TOR occupancy by the peptide/MHC ligands. Our data argue that T cell responses are triggered by a cumulative signal which is reached at different time points for different TCR ligands.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据